Dr. Harihara Mehendale

Publications

51.	Devi, S., Palkar, P. S., and Mehendale, H. M (2007) Measuring covalent binding in toxicity. Chapter 2: Assessment of Liver Toxicity. In Cuttent Protocols in Toxicology (E. Hodgson, Ed.) John Wiley, Somerset, NJ., in press
50.	Mehendale, H. M. (2007) Role of tissue repair in liver injury. In (Kaplowitz, N and DeLeve, L. Eds) Drug-Induced Liver Disease, Second Edition, Informa Healthcare, Philadelphia, USA. in press
49.	Wang, T., Shankar, K., Ronis, M. J. J. and Mehendale, H. M. (2007) Mechanisms and outcomes of drug and toxicant-induced liver toxicity in diabetes. Crit. Rev. Toxicol. 37:in press
48.	Chalakapati, J., Korrapati, M. C., Shankar, K., Hill, R. A., Warbritton, A., Latendrese, J. R. and Mehendale, H. M. (2007) Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: effects of diet restriction and phenobarbital. Toxicol. Appl. Pharmacol. 219:in press
47.	Chilakapati, J., Korrapati, M. C., Hill, R. A., Warbritton, A., Latendresse, J. R., and Mehendale, H. M. (2007) Role of thioacetamide sufoxide in saturatioin toxicokinetics of thioacetamide. Toxicology 230:in press
46.	Donthamsetty, S., Bhave, V. S., Mitra, M. S., Latendresse, J. R., and Mehendale, H. M. (2007) Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology 45: in press
45.	Philip, B. K., Mumtaz, M. M., Latendresse, J. R. and Mehendale, H. M. (2007) Effect of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology, 229: in press.
44.	Devi, S. S., Philip, B. K., Reddy, R. N., Warbritton, A., Latendresse, J. R. and Mehendale, H. M. (2006) Prior administration of a low dose of thioiacetamide protects type 1 diabetic rats from subsequent administration of a lethal dose of thioacetamide. Toxicology 226:107-117.
43.	Philip, B. K., Anund, S. S., Palkar, P. S., Mumtaz, M. M., Latendrese, J. R. and Mehendale, H. M. (2006) Subchronic chloroform priming protects mice from a subsequently administered lethal dose of chloroform. Toxicol. Appl. Pharmacol. 216:108-121.
42.	Dnayanmote, A. V., Sawant, S. W., Lock, E. A., Latendresse, J. R., Warbritton, A. A. and Mehendale, H. M. (2006) Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-L-cysteine (DCVC)-initiated renal injury and renal faliure in diabetes. Toxicol. Appl. Pharmacol. 215:146-157.
41.	Limaye, P. B., Apte, U. M., Yu, S., Bhave, V. S., Palkar, P. S., Sawant, S. P., Latendresse, J. L., Reddy, J. K., and Mehendale, H. M. (2006) Upregulation of calpastatin in regenerating and developing livers: role of resistance against hepatotoxicity. Hepatology 44:379-388.
40.	Korrapati, M. C., Chilakapati, J., Lock, E. A., Latendresse, J. R., Warbritton, A. and Mehendale, H. M. (2006) Preplaced cell division - a crictical mechanism of dichlorovinyl-L-cysteine-induced autoprotection in mice. Amer. J. Physiol. Renal Physiol. 291:F439-F455.
39.	He, L., Simmen, F. A., Mehendale, H. M., Ronis, M. J. J., and Badger, T. M. (2006) Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. J. Biol. Chem. 281 (16):11126-11134.
38.	Anand, S. S., Philip, B. K., Palkar, P. S., Mumtaz, M. M., Latendresse, J. R., and Mehendale, H. M. (2006) Adaptive resistance in mice upon subchronic exposure to chloroform: increased exhalation and target tissue regeneration. Toxicol. Appl. Pharmacol. 213:267-281.
37.	Devi, S. S. and Mehendale, H. M. (2006) Microarray analysis of thioacetamide-treated type 1 diabetic rats. Toxicol. Appl. Pharmacol. 213:69-78.
36.	Sawant, S. P., Dnyanmote, A. V., Warbritton, A., Latendresse, J. R. and Mehendale, H. M. (2006) Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity. J. Pharmacol. Exp. Ther. 316:507-519.
35.	Reddy, N. M., Latendresse, J. R. and Mehendale, H. M. (2006) Colchicine antimitosis causes progression of DCVC-induced injury leading to acute renal faliure and death in mice. Toxicology, 507-519.
34.	Dnayanmote, A. V., Sawant, S. P., Lock, E. A., Latendresse, J. R., and Mehendale, H. M. (2006) Diabetic mice are protected from normally lethal nephropathy of 1,2-dichlorovinyl-L-cysteine (DCVD): role of nephrogenic tissue repair. Toxicol. Appl. Pharmacol. 211:133-147.
33.	Sawant, S. P., Dnyanmote, A. V., Warbritton, A., Latendresse, J. R. and Mehendale, H. M. (2006) Type 2 diabetic rats are sensitive to thioacetamide hepatotoicity. Toxicol. Appl. Pharmacol. 211:221-232.
32.	Chilakapati, J., Shankar, K., Korrapati, M. D., Hill, R. N. and Mehendale, H. M. (2005) Saturation toxicokinetics of thioacetamide: role in development of liver injury. Drug Metab. Dispos. 33:1877-1885.
31.	Devi, S. S., Warbritton, A., Latendresse, J. R., and Mehendale, H. M. (2005) Impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats: Role of NF-kB signaling. Eur. J. Pharmacol. 523:127-132.
30.	Devi, S. S. and Mehendale, H. M. (2005) Disrupted G1 to S phase clearance via cyclin signaling explains impaired live tissue repair in thioacetamide-treated type 1 diabetic rats. Toxicol. Appl. Pharmacol. 207:85-102.
29.	Anand, S. S., Mumtaz, M. M. and Mehendale, H. M. (2005) Dose-dependent liver tissue repair in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity. Arch. Toxicol. 79:671-682.
28.	Korrapati, M. C., Lock, E. A. and Mehendale, H. M. (2005) Molecular mechanisms of enhanced cell division in protection against 1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death. Amer. J. Physiol. Renal Physiol. 289:F175-F185.
27.	Anand, S. S., Mumtaz, M. M. and Mehendale, H. M. (2005) Liver tissue repair is dose-dependent in chloroform plus trichloroethylene sub-additive liver injury. Basic Clin. Pharmacol. Toxicol. 96:346-444.
26.	Mehendale, H. M. and Limaye, P. B. (2005) Calpain: A deat protein that mediates progression of liver injury. 'Opinion' Article, Trend Pharmacol. Sci. 26:232-236.
25.	Mehendale, H. M. (2005) Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol. Pathol. 33:41-51.
24.	Corton, C. J., Apte, U. M., Anderson, S. P., Limaye, P. B., Yoon, L., Latendresse, J. R., Dunn, C., Everitt, J. L., Voss, K. A., Swanson, C., Kinbrough, C., Wond, J. S., Gill, S. S., Chandraratna, R. A. S., Kwak, M.M. K., Kensler, T. W., Stulnig, T. M., Steffensen, K. R., Gustafsson, J. K., and Mehendale, H. M. (2004) Mimetics of calorie restriction include agonists of lipid-activated nuclear receptors. J. Biol. Chem. 279(44):46204-46212.
23.	Anand, S. S., Murthy, S. N., Vaidya, V. S., Mumtaz, M. M. and Mehendale, H. M. (2004) Liver regeneration: critical toxicodynamic response in predictive toxicology. Environ. Toxicol. Pharmacol. 18:149-160.
22.	Anand, S. S., Murthy S. N., Vaidya, V. S., Mumtaz, M. M. and Mehendale, H. M. (2004) Dose-dependent liver tissue repair in chloroform plus thioacetamide acute hepatotoxicity. Environ. Toxicol. Pharmacol. 18:143-148.
21.	Murali, B., Korrapati, M. C., Warbritton, A., Latendresse, J. L., and Mehendale, H. M. (2004) tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity. Mechan. Ageing Develop. 125:421-435.
20.	Sawant, S. P., Dnyanmote, A., Shankar, K., Limaye, P. B., Latendresse, J. R., and Mehendale, H. M. (2004) Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. J. Pharmacol. Exp. Ther. 308:690-704.
19.	Vaidya, V. S., Shankar, K., Lock, E. A., Dixon, D. and Mehendale, H. M. (2003) Molecular mechanisms of nephrogenic tissue repair in survival from acute renal tubular necrosis: role of ERK1/2 pathway. Toxicol. Pathol. 31:604-618.
18.	Limaye, P. B., Apte, U. M., Bucci, T. J., Warbritton, A., and Mehendale, H. M. (2003) Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 191:211-226.
17.	Shankar, K., Vaidya, V. S., Corton, C. J., Bucci, T. J., Liu, J., Waalkes, M. P., and Mehendale, H. M. (2003) Activation of PPAR-a in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 17:1748-1750. (This printed publication is still in press. However, the longer version has just been published online. FASEB J. express article 10.1096.fj.02-1186fje. Published July 18, 2003.)
16.	Anand, S. S., Vaidya, V. S., Murthy, S. N., Soni, M. G., Mumtaz, M. M. and Mehendale, H. M. (2003) Tissue repair plays pivotal role in final outcome of liver injury following chloroform, and allyl alcohol binary mixture. Food Chem. Toxicol. 41:1123-1132.
15.	Shankar, K., Vaidya, V. S., Wang, T., Manautou, J. E., Ronis, M. J. J., Bucci, T. J., and Mehendale, H. M. (2003) Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol. Sci. 73:220-234.
14.	Shankar, K., Vaidya, V. S., Want, T., Bucci, T. J. and Mehendale, H. M. (2003) Streptozotocin-induced diabetic mice are resistent to lethal effects of thioacetamide hepatotoxicity. Toxicol. Appl. Pharmacol. 188:122-134.
13.	Vaidya, V. S., Shankar, K., Lock, E. A>, Bucci, T. J. and Mehendale, H. M. (2003) Renal injury and repair following 1,2-dichlorovinyl L-cysteine (DCVC) administration to mice. Toxicol. Appl. Pharmacol. 188:110-121.
12.	Vaidya, V. S., Shankar, K., Lock, E. A., Bucci, T. J. and Mehendale, H. M. (2003) Role of tissue repair in protection from S-1,2-dichlorovinyl-L-cysteine (DCVC)-induced acute renal tubular necrosis in the mouse. Toxicol. Sci. 74:215-227.
11.	Apte, U. M., Limaye, P. B., Ramaiah, S. K., Desaiah, D., Bucci, T. J., Warbritton, A. and Mehendale, H. M. (2003) Mechanisms of higher liver tissue repair and survival in diet restricted rats treated with thioacetamide. Toxicol. Sci. 72:272-282.
10.	Anand, S., Soni, M. G., Vaidya, V. S., Mumtaz, M. M. and Mehendale, H. M. (2003) Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform. Internal. J. Toxicol. 22:25-33.
9.	Apte, U. M., Limaye, P. B., Ramaiah, S. K., Vaidya, V. S., Bucci, T. J., Warbritton, A. and Mehendale, H. M. (2002) Upregulated promitogenic signalling via cytokines and growth factors: potential mechanism of robust liver tissue repair in caloric restricted rats upon toxic injury. Toxicol. Sci. 69:448-459.
8.	Wang, T., Shankar, K., Bucci, T. J., Warbritton, A., and Mehendale, H. M. (2001) Diallyl sulfide inhibitioin of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality. Toxicol. Appl. Pharmacol. 173:27-37.
7.	Ramaiah, S. K., Apte, U.M., and Mehendale, H. M. (2001) CYP2E1 induction as a mechansism for increased thioacetamide liver injury in diet restricted rats. Drug Metab. Dispos. 29:1088-1095.
6.	Mehendale, H. M. (2000) PPAR-alpha: A key to the mechanism of hepatoprotection by clofibrate. Toxicological Highlight. Toxicol. Sci. 57:187-190.
5.	Mbonifor, J. N., Chigbp, F. E., and Mehendale, H. M. (2000) Polyamine protection against chemically induced hepatotoxicity. Internat. J. Toxicol. 19:391-400.
4.	Ramaiah, S. K., Apte, U. M., and Mehendale, H. M. (2000) Diet restriction as a protective mechanism in noncancer toxicity outcomes: A review. Internat. J. Toxicol. 19:413-424.
3.	Wang, T., Shankar, K., Ronis, M. J. J. and Mehendale, H. M. (2000) Potentiation of thioacetamide liver injury in diabetic rats is due to CYP2E1. J Pharmacol. Exp. Ther. 294:473-479.
2.	Wang, T., Fontenot, R. D., Soni, M. G., Bucci, T. J., and Mehendale, H. M. (2000) Enhanced hepatotoxicity and toxic outcome in thioacetamide-induced diabetic rats. Toxicol. Appl. Pharmacol. 166:92-100.
1.	Barton, C. C, Bucci, T. J., Lomax. L. G., Warbritton, A. and Mehendale, H. M. (2000) Alpha-naphthylthiourea autoprotection: Possible roleof augmented cell divisioin and tissue repair processes. Toxicology 143:167-181.